Myocardial depression secondary to alcohol is initially reversible however prolonged sustained alcohol use leads to irreversible dysfunction. Alcohol-induced cardiomyopathy treatment includes a combination of lifestyle modifications, pharmacological treatment, management of arrhythmia, and supportive care. Furthermore, there are conflicting data among studies regarding the prognosis of the condition, with some showing overall mortality near 60% and others showing a mortality rate of only 19% (Table (Table11). Additionally, the accepted ACM definition does not take into account a patient’s sex or body mass index (BMI). As women typically have a lower BMI than men, a similar amount of alcohol would reach a woman’s heart after consuming smaller quantities of alcohol. The status of all patients was followed up by telephone interview, outpatient clinic attendance, or hospitalization during the follow-up period.
The role of mitochondrial dysfunction in the pathogenesis of diabetic cardiomyopathy
Prior studies have investigated the impact of ethanol on changes in the activity and levels of oxidative enzymes. Catalase activity is significantly increased in postmortem heart samples acquired from people who have been diagnosed with ACM. Other studies investigated the catalase levels and activity among rats with ACM with a control group. This may be explained by the fact that the increased catalase activity in those who have a long history of alcohol abuse may represent a protective and adoptive reaction to the persistent high ethanol levels [11]. Basing on epidemiological data, alcoholic cardiomyopathy represents one of the main cause of non-ischemic dilated cardiomyopathy in Western countries [5]. Similarly to alcoholic liver disease, the diagnosis of AC is still based on exclusion criteria; in particular, an excessive alcohol consumption can be evidenced in up to 40% of cases of dilated cardiomyopathy [6].
Echocardiographic and haemodynamic studies in alcoholics
The study suggests that the MAPK signaling pathway may be an effective intervention target for DCM (Wu et al., 2022). In another study, celastrol can also alleviate diabetes-induced cardiac damage, inhibit mitochondrial ROS production, and suppress the release of inflammatory factors. The research alcoholic cardiomyopathy is especially dangerous because results indicate that celastrol shows great potential as an effective cardiac protective drug for treating DCM (Zhao et al., 2023). According to current knowledge, prolonged and excessive alcohol consumption plays a significant role in inducing oxidative stress within the myocardium.
New Treatment Strategies for Alcohol-Induced Heart Damage
Some studies have shown that the combination of carvedilol and trimetazidine with other traditional heart failure medications is effective [1-3,7-11,16-20]. The achievement of total alcohol abstinence represents the most effective strategy for the treatment of alcohol-induced ogan damage, including alcoholic cardiomyopathy, in order to promote the recovery of left ventricular dysfunction [4], [11]. However, the limit between reversible and non-reversible damage, in other words the “point of no-return”, is currently not known [12]. https://ecosoberhouse.com/article/is-it-possible-to-get-sober-without-aa/ Hypertension due to alcohol may be a confounding comorbidity in that it may contribute to LV dysfunction; therefore, LV dysfunction due to hypertension must be differentiated from pure AC. Alcohol-induced cardiomyopathy remains a relevant health problem, for which the mainstay of treatment is alcohol abstinence. In recent years, basic and clinical research has shed light on its pathogenesis, which includes direct toxic effects of alcohol on the myocardium, oxidative stress, mitochondrial dysfunction, and genetic susceptibility.
- Overall, your healthcare provider is the best source of information and answers when it comes to your recovery.
- As pointed out before, the current accepted definition of ACM probably underestimates the number of women affected by the disease.
- Recent reports indicate that terpenoids may also improve the development of diabetes cardiomyopathy by regulating mitochondrial function (Zhang et al., 2024).
- In many — if not most — cases, abstaining from alcohol can be enough to help people recover from alcohol-induced cardiomyopathy.
- Initial assessment of all patients included physical examination, blood tests, 12-lead electrocardiography (ECG) and 2D echocardiography.
Astragalus polysaccharides are water-soluble polysaccharides extracted from the dried roots of Astragalus membranaceus (Fisch.) Bunge, which have anti-oxidant, anti-inflammatory, anti diabetes, immune regulation and other biological activities (Dong et al., 2023). Studies by Sun et al. have shown that astragalus polysaccharides (0.1–3.2 mg/mL, 24 h) can inhibit HG-induced H9C2 cell apoptosis by up-regulating the expression of Bcl-2, down-regulating the expression of Bax, and increasing the ratio of Bcl-2/Bax in the mitochondria (Sun et al., 2017). In another study, Chen et al. demonstrated that astragalus polysaccharides can protect the ultrastructure of cell mitochondria, reduce cell apoptosis, increase SOD activity, and thereby reduce oxidative stress induced by HG in H9C2 cells (Chen et al., 2018). In conclusion, these results prove that astragalus polysaccharides can prevent and treat DCM through the mitochondria-mediated apoptotic pathway. Flavonoids are secondary metabolites of plants, characterized by compounds with a 2-phenylchromen-4-one structure, widely present in plants.
Screening for Dilated Cardiomyopathy in At-Risk First-Degree Relatives
